Models of Cartilage Injury: in Vitro and in Vivo
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چکیده
Introduction: Cartilage injury is one of the most significant factors leading to secondary osteoarthritis. Several studies have demonstrated cartilage matrix damage and chondrocyte death in response to mechanical injury. Recently it has been shown that chondrocytes undergo apoptosis when subjected to mechanical trauma. This study presents several models of cartilage injury ranging from in vitro to in vivo that can be used to study this phenomenon. Validation of these models is provided with clinical data.
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